Brain tsunami as a mechanism of spreading cell death in subarachnoidal hemorrhage

The brain tsunami in the form of spreading depolarization, in which neurons undergo self-propagating waves of an electrical depolarization, has been shown to contribute to the pathogenesis of early brain injury after subarachnoidal hemorrhage.

Terminal spreading depolarization and electrical silence in brain death
A standard compensatory response to cell depression would be vasodilation of small blood vessels in the area, but in spreading depolarization, pathogenic vasoconstriction also occurs, causing even more significant harm.
Suppression of these depolarizations might one day become an essential tactic for minimizing acute brain injury as it evolves in the emergency setting. Possible candidates for medicamentous treatment are calcium channel blockers.

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