High blood pressure alter stem cells of the bone marrow

Scientists at the Baker Heart and Diabetes Institute have found that high blood pressure caused by specific signaling from the brain promotes heart disease by altering stem cells with the bone marrow.

Figure 2.
The cause lies in an overactive sympathetic nervous system that can instruct bone marrow stem cells to produce more white blood cells that clog up blood vessels. These findings suggest that elevated blood pressure driven by the sympathetic nervous system can influence mechanisms that modulate the hematopoietic system to promote atherosclerosis and contribute to cardiovascular events.


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