Moderate levels of vitamin A in the intestine prevent the immune system from becoming overactive

Vitamin A is obtained from the diet and is metabolized by intestinal epithelial cells (IECs), which operate in intimate association with microbes and immune cells.

Vitamin A regulates transcriptional programs that drive protective or pathogenic immune responses in the intestine, in a manner dependent on its concentration, herewith moderate levels of it prevent the immune system from becoming overactive.

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