At the same time, two studies (the first in people without diabetes (ARRIVE: A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease) and the second in people with diabetes (ASCEND: A Study of Cardiovascular Events iN Diabetes)) came to one conclusion.
It turned out that with prolonged use of 100 mg aspirin in primary prevention, the risk of bleeding twice is higher than risk incidences of acute cardiovascular events. Herewith no effect on gastrointestinal or any other cancer was seen. Similar results of both studies can be explained by the principle of symmetry. It is important to note, however, that the medication is effective in secondary prevention in both populations, and in real life often difficult to recognize the boundary between the situations for primary and secondary prevention.
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